After a decade as the anchor of "NBC Nightly News," Lester Holt is starting a new chapter in his journalism career. | USA TODAY Video

Lester Holt signs off at the end of his first broadcast as anchor of #NBCNightlyNews | NBC Nightly News with Tom Llamas

As Lester Holt signs off from his final broadcast at Nightly News, we share some of his most memorable moments along the way - the news he covered, the people he met, the stories we all shared. | NBC Nightly News with Tom Llamas

Gov. Cuomo responds to President Trump, who said he doesn't believe New York needs 30,000 ventilators. "I hope no one needs a ventilator," Cuomo told Lester Holt today. "But I don't operate on what I hope...I operate on the data..." Watch the interview tonight on Nightly News. | NBC Nightly News with Tom Llamas

TONIGHT: Lester Holt interviews Dr. Anthony Fauci as the US adds travel restrictions in response to the Omicron Covid-19 variant. We'll have the latest tonight on NBC Nightly News at 6:30 ET / 5:30 CT (check your local NBC station listings). Read more: https://nbcnews.to/3p4LxV5 | NBC Nightly News with Tom Llamas

"One pill could kill. One pill, one time, game over." Tonight on NBC Nightly News, Lester Holt talks to Cheri Oz, Special Agent in Charge of the DEA's Phoenix Field Division, about the fentanyl crisis. Watch the full report at 6:30 pm ET / 5:30 pm CT (check local listings). | NBC Nightly News with Tom Llamas